Faculty Advisor

Heilman, Destin

Abstract

Porcine Circovirus Type 2 (PCV2) contains a protein, VP3, that can induce apoptosis in cancerous cells. PCV2 is commonly compared to Chicken Anemia Virus (CAV) because of its similar protein apoptin, which also induces apoptosis in cancerous cells. An increase in nuclear accumulation when PCV2 VP3 cells were treated with Leptomycin B provided evidence that PCV2 VP3 may utilize the same CRM1 pathway that apoptin does, but it is not the only method at work. The proteins were then cotransfected, but did not show any changes in localization. The conjunction of the results illustrate that although the two viruses may carry out a similar function, they may utilize completely different mechanisms.

Publisher

Worcester Polytechnic Institute

Date Accepted

August 2013

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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