Porcine Circovirus Type 2 (PCV2) contains a protein, VP3, that can induce apoptosis in cancerous cells. PCV2 is commonly compared to Chicken Anemia Virus (CAV) because of its similar protein apoptin, which also induces apoptosis in cancerous cells. An increase in nuclear accumulation when PCV2 VP3 cells were treated with Leptomycin B provided evidence that PCV2 VP3 may utilize the same CRM1 pathway that apoptin does, but it is not the only method at work. The proteins were then cotransfected, but did not show any changes in localization. The conjunction of the results illustrate that although the two viruses may carry out a similar function, they may utilize completely different mechanisms.
Worcester Polytechnic Institute
Biology and Biotechnology
Major Qualifying Project
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Chemistry and Biochemistry