MacDonald, John C.
Porous metallic-organic frameworks (MOFs) consisting of crystalline coordination polymers are of interest as materials for heterogeneous catalysis. We currently are exploring the activity of copper-containing MOFs (Cu-MOFs) for catalyzing Huisgen 1,3-dipolar cycloaddition (“Click”) reactions between substituted alkynes and azides. Our goals were to determine if Cu-MOFs show catalytic activity, and whether the sorbent properties and high density of metal ions present in Cu-MOFs lead to more efficient catalysis of Click reactions compared to homogeneous catalysts. Toward that goal, this research has focused in two areas: (1) synthesis of substituted triazoles via the “Click” reaction using the Cu-MOF Cu(im)2 as the catalyst; and (2) investigation of the reaction rates for those reactions.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry