Faculty Advisor

Camesano, Terri Anne

Abstract

Potential commercial applications of nanoparticles have raised concern regarding their toxicological effects with respect to humans and the environment. The goals of this project were to examine the effect of chemical functionalization and surface charge on the interaction between nanoparticles and cell membranes and to predict nanoparticle behavior in the environment using humic acid polymer. Humic acid polymer either decreased or altered the mechanism of interaction depending on surface charge and chemical functionalization. Additionally, chemical functionalization and surface charge influenced the extent to which cell membrane integrity was disrupted. Membrane integrity was disrupted by two mechanisms: nanoparticle adsorption to the membrane and fracturing of the membrane.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Chemical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemical Engineering

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