Camesano, Terri Anne
Potential commercial applications of nanoparticles have raised concern regarding their toxicological effects with respect to humans and the environment. The goals of this project were to examine the effect of chemical functionalization and surface charge on the interaction between nanoparticles and cell membranes and to predict nanoparticle behavior in the environment using humic acid polymer. Humic acid polymer either decreased or altered the mechanism of interaction depending on surface charge and chemical functionalization. Additionally, chemical functionalization and surface charge influenced the extent to which cell membrane integrity was disrupted. Membrane integrity was disrupted by two mechanisms: nanoparticle adsorption to the membrane and fracturing of the membrane.
Worcester Polytechnic Institute
Major Qualifying Project
All authors have granted to WPI a nonexclusive royalty-free license to distribute copies of the work, subject to other agreements. Copyright is held by the author or authors, with all rights reserved, unless otherwise noted.