Student Work

THE EFFECT OF A PUTATIVE CHROMATIN-OPENING ELEMENT ON METHOTREXATE AMPLIFICATION

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Previous work at Abbott Bioresearch Center on a putative chromatin-opening sequence inserted into a plasmid dubbed "genomic vector", suggested that the vector caused an increase in the rate of methotrexate-induced amplification in Chinese Hamster Ovary cells. This project supported the hypothesis that the genomic sequence may cause an increase in amplification effects; however, the increase was not statistically significant, nor was the increase in expression of antibody in CHO cells when compared to the parental vector.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-122007-173047
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  • 2007
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  • 2007-12-20
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