Faculty Advisor

Adams, David S.

Abstract

Previous work at Abbott Bioresearch Center on a putative chromatin-opening sequence inserted into a plasmid dubbed "genomic vector", suggested that the vector caused an increase in the rate of methotrexate-induced amplification in Chinese Hamster Ovary cells. This project supported the hypothesis that the genomic sequence may cause an increase in amplification effects; however, the increase was not statistically significant, nor was the increase in expression of antibody in CHO cells when compared to the parental vector.

Publisher

Worcester Polytechnic Institute

Date Accepted

December 2007

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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