Faculty Advisor

Adams, David S.

Abstract

Alzheimer's disease (AD) is initiated by the formation of extracellular amyloid-B (AB) neurotoxin. Our laboratory uses neurotrophic factor (NTF) mimetics to increase neuronal survival in the presence of AB. This project investigated the potential role of cathepsin-D in AB-induced cell death, and found through fluorescence substrate assay that cathepsin-D activity increases in AB-treated human neuronal cells. We also found that NTF treatment can increase the cellular levels of therapeutic anti-oxidative superoxide dismutase in the brains of AD mice.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2011

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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