Faculty Advisor

Buckholt, Michael Allan

Faculty Advisor

Rulfs, Jill

Abstract

Promensil is an over-the-counter phytoestrogen supplement, originally intended to treat menopause, which has been shown to decrease breast cancer proliferation. This project examined this effect of Promensil, based on the estrogen receptor beta (ER-B). Using T47D cells with a tetracycline tunable ER-B, a decrease in cell proliferation was observed, but with no correlation to ER-B. Rather, Promensil appeared to compete with 17B-estradiol for estrogen receptor alpha. For the future, the correlation between ER-a and the phytoestrogen components of Promensil should be studied.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2018

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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