Faculty Advisor

Adams, David S.

Center

University of Massachusetts Medical Center

Abstract

Prostate cancer (PC) is a leading cause of death for men because of metastasis of the tumor to the skeleton. Using mouse models, we find that Runx2, a transcription factor implicated in PC progression, is present in stromal and epithelial cells of the early PIN (prostatic intraepithelial neoplasia) lesion in the prostate. Runx2 activates target genes involved in metastasis in the prostate by week 16. These results indicate a potential new therapy, focused on Runx2, for prostate cancer.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2012

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Project Center

University of Massachusetts Medical Center

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