Faculty Advisor

Adams, David S.

Abstract

Prostate cancer cell functions are regulated by elaborate signaling pathways activated by extracellular stimuli. The integrin family of cell surface receptors is known to activate intracellular pathways in response to signals generated via specific interactions with the extracellular matrix. Through the use of immunohistochemistry and immunoblotting, this study shows that the alpha-v beta-6 integrin is predominately expressed in epithelial cells in human preneoplastic, prostate intraepithelial neoplasia, proliferative inflammatory atrophy lesions and prostatic adenocarcinoma. The results indicate that alpha-v beta-6 is highly expressed in areas with infiltrating leukocytes, and is expressed focally in malignant and some benign prostate glands, but not in normal prostate tissue.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2006

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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