Student Work

Murine Prostate Cancer Development and Alpha V Beta 6 Integrin Expression In The Pten-Null Mouse Model of Prostate Cancer

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Prostate cancer is projected to account for 27,000 deaths in the U.S. in 2007 (Jemal et al, 2007). Although much research has been conducted, the exact mechanisms of prostate cancer initiation and development are unknown. This MQP assessed the development of prostatic intraepithelial neoplasia (PIN) and adenocarcinoma, versus the expression of alpha V beta 6 integrin which has previously been implicated in other types of cancer signaling, at different time points in the specific background of PTEN-null mice, a model for prostate cancer. It was determined that integrin alpha V beta 6 was expressed in some stages of both PIN and adenocarcinoma.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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Identifier
  • E-project-010308-234631
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Year
  • 2008
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Date created
  • 2008-01-03
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Last modified
  • 2023-10-06

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