Faculty Advisor

Adams, David S.


Prostate cancer is projected to account for 27,000 deaths in the U.S. in 2007 (Jemal et al, 2007). Although much research has been conducted, the exact mechanisms of prostate cancer initiation and development are unknown. This MQP assessed the development of prostatic intraepithelial neoplasia (PIN) and adenocarcinoma, versus the expression of alpha V beta 6 integrin which has previously been implicated in other types of cancer signaling, at different time points in the specific background of PTEN-null mice, a model for prostate cancer. It was determined that integrin alpha V beta 6 was expressed in some stages of both PIN and adenocarcinoma.


Worcester Polytechnic Institute

Date Accepted

January 2008


Biology and Biotechnology

Project Type

Major Qualifying Project



Advisor Department

Biology and Biotechnology

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