Faculty Advisor

Burnham, Nancy A.

Abstract

Proteins are essential for all cellular processes. Hemoglobin is one of the most well studied proteins and is the standard model for allosteric regulation. Allostery is an important, yet poorly understood, component of biochemistry. Using Normal Mode Analysis (NMA), the dynamics of scapharca dimeric hemoglobin, an allosteric protein,have been simulated and correlate with previous crystallographic data. This indicates that NMA may be a useful tool for predicting early intermediate structures and explaining allosteric regulation at the molecular level.

Publisher

Worcester Polytechnic Institute

Date Accepted

March 2007

Major

Physics

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Physics

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