Burnham, Nancy A.
Proteins are essential for all cellular processes. Hemoglobin is one of the most well studied proteins and is the standard model for allosteric regulation. Allostery is an important, yet poorly understood, component of biochemistry. Using Normal Mode Analysis (NMA), the dynamics of scapharca dimeric hemoglobin, an allosteric protein,have been simulated and correlate with previous crystallographic data. This indicates that NMA may be a useful tool for predicting early intermediate structures and explaining allosteric regulation at the molecular level.
Worcester Polytechnic Institute
Major Qualifying Project
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