Faculty Advisor

Adams, David S.

Abstract

Pulmonary Arterial Hypertension (PAH) is a devastating disease characterized by a persistent increase in pulmonary arterial resistance. Endothelin is a hormone involved in maintaining vasoconstriction, but the enzymes and proteins involved in its signaling pathway are not fully known. Understanding the endothelin-B (ETB) signaling pathway is crucial for the development of a more specific endothelin-targeted therapy for PAH. Therefore, the objective of this project was to identify mediators utilized by the ETB receptor and help determine their function in the regulation of ATP neurotransmitter release. In rat PC12 cells differentiated by neuronal growth factor, the inhibition of PLC was shown to reduce ETB-mediated ATP release.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2010

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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