Student Work

Neurotransmitter Signal Transduction and its Role in Pulmonary Arterial Hypertension Vasodilatation and Vasoconstriction

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Pulmonary Arterial Hypertension (PAH) is a devastating disease characterized by a persistent increase in pulmonary arterial resistance. Endothelin is a hormone involved in maintaining vasoconstriction, but the enzymes and proteins involved in its signaling pathway are not fully known. Understanding the endothelin-B (ETB) signaling pathway is crucial for the development of a more specific endothelin-targeted therapy for PAH. Therefore, the objective of this project was to identify mediators utilized by the ETB receptor and help determine their function in the regulation of ATP neurotransmitter release. In rat PC12 cells differentiated by neuronal growth factor, the inhibition of PLC was shown to reduce ETB-mediated ATP release.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042910-112415
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  • 2010
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  • 2010-04-29
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Permanent link to this page: https://digital.wpi.edu/show/n870zs200