Faculty Advisor

Adams, David S.

Abstract

Rac1 is a member of a family of small GTPases that are primarily responsible for cellular motility and morphology. Activation of Rac1 by Rac-specific guanine nucleotide exchange factors (GEFs) is thought to be important for the metastasis of cancer cells. The scope of this project was to synthesize a minimal extended peptide sequence that would block interaction between Rac1 and the Rac1-specifice exchange factor GEF-H1. Inhibition of Rac1 activation by Rac-specific GEFs would be a useful tool for the study of Rac-mediated cellular processes and may ultimately result in cancer therapeutics.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2006

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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