Adams, David S.
Rac1 is a member of a family of small GTPases that are primarily responsible for cellular motility and morphology. Activation of Rac1 by Rac-specific guanine nucleotide exchange factors (GEFs) is thought to be important for the metastasis of cancer cells. The scope of this project was to synthesize a minimal extended peptide sequence that would block interaction between Rac1 and the Rac1-specifice exchange factor GEF-H1. Inhibition of Rac1 activation by Rac-specific GEFs would be a useful tool for the study of Rac-mediated cellular processes and may ultimately result in cancer therapeutics.
Worcester Polytechnic Institute
Major Qualifying Project
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Biology and Biotechnology