Faculty Advisor

Srinivasan, Jagan

Abstract

Alzheimer’s disease is the fifth leading cause of death in the US. This neurodegenerative disease involves neuronal death associated with amyloid-beta (AB) plaques. Current treatments can manage symptoms, but there is no cure for Alzheimer’s disease. Our study focused on C. elegans models of Alzheimer’s disease and the ability of punicalagin and tannic acid, plant polyphenols, to prevent the onset of disease symptoms. Behavioral assays were used to study the ability of these extracts to combat the effects of AB expression in C. elegans. These assays tested chemosensory and muscular deficits, similar to olfactory defects and paralysis seen in patients. Our results suggest that punicalagin reduces neuronal deficits caused by the expression of AB, while tannic acid does not.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2016

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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