Faculty Advisor

Adams, David S.

Abstract

Recent models for carcinogenesis propose a strong role for stem cells and their potential for immortality. It is unclear whether cervical stem cells exist, thus their potential role in cervical cancer has not been investigated. This project used immunofluorescence microscopy to locate areas which may contain stem cells in normal human cervical tissue. Antibodies were used against known stem cell markers: ABCG2, alpha-k15, Oct-3/4, Tenascin-C, CD 133, and CD 200. The alpha-k15, and Tenascin-C data for cervical tissue versus skin controls indicate that stem cells may be present in the squamous epithelium of the cervix.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2007

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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