Faculty Advisor

Farny, Natalie

Abstract

Recently, microglia were found to have roles in synaptic pruning, synaptic stripping, and neuroprotection. Through these studies an interesting phenomenon of microglia making soma-to-soma contact, “hugging”, with cortical neurons was observed. The goal of this study was to use transgenic mice to define hugging behavior throughout post-natal neuronal development. Specifically, how many soma-to-soma contacts were being made by microglia and what types of neurons were being contacted. I further investigated the role of AMIGO1, a cell adhesion molecule found in neurons and glia, in hugging behavior. Understanding normal microglial-neuronal interactions in the healthy brain is relevant to many neurodevelopmental diseases.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2017

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

BIO

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