Faculty Advisor

Weathers, Pamela

Abstract

Recently, the malaria-causing parasite Plasmodium falciparum has acquired resistance to treatment with pure artemisinin, a drug compound produced by the plant Artemisia annua. Oral consumption of dried leaves of Artemisia annua has been proposed as an effective and more affordable therapeutic alternative. To investigate this treatment, Caco-2 cell monolayers were used to study the effect of two flavonoids, quercetin (Q) and rutin (R), on artemisinin (AN) transport and bioavailability. This study demonstrated that quercetin and rutin may have increased artemisinin transport.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2014

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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