Faculty Advisor

Srinivasan, Jagan

Center

UMMC / University of Massachusetts Medical Center

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which affects motor neurons in the brain and spinal cord. This project analyzed the ALS-associated protein, profilin 1 (PFN1). Multiple experiments were completed in order to analyze what occurs when profilin is not functioning correctly. Cloning, transfection, creating knockdown lines, and observing cells using fluorescent imaging where among the tools used to analyze wildtype PFN1 and ALS-mutant PFN1.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2016

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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