University of Massachusetts Medical Center
Dr. Craig Mello
RNA interference (RNAi) is a sequence-specific silencing phenomenon that is conserved in animals, plants and some bacteria (Fire and Mello, 1998; Meister and Tuschl, 2004). At least 4 different AGO pathways are thought to function in the germline of C. elegans. In an effort to understand how these pathways remain independent from one another, we are using yeast two-hybrid to identify proteins that interact with and potentially regulate AGOs. The results showed colonies which grew on secondary selection plates indicated potential interacting proteins for the argonautes of interest.
Worcester Polytechnic Institute
Biology and Biotechnology
Major Qualifying Project
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Chemistry and Biochemistry
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