Faculty Advisor

Heilman, Destin

Center

UMMC / University of Massachusetts Medical Center

Abstract

RNA interference (RNAi) is a sequence-specific silencing phenomenon that is conserved in animals, plants and some bacteria (Fire and Mello, 1998; Meister and Tuschl, 2004). At least 4 different AGO pathways are thought to function in the germline of C. elegans. In an effort to understand how these pathways remain independent from one another, we are using yeast two-hybrid to identify proteins that interact with and potentially regulate AGOs. The results showed colonies which grew on secondary selection plates indicated potential interacting proteins for the argonautes of interest.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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