RUNX transcription factors are a family of DNA-binding proteins that function in development and hematopoiesis. Mixed Lineage Leukemias (MLL) are dependent on RUNX1 for oncogenic activity, but it is unclear whether MLLs are also affected by RUNX2. In this project, RUNX2 was knocked down in a variety of MLL-derived cell lines using shRNAs, and the levels of leukemic cell apoptosis were monitored by FACS. If found to be required for MLL, this would identify RUNX2 as a new therapeutic target.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Solon, April Louise

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042717-113513

Advisor

• Adams, David S.

Year

• 2017

Sponsor

• Lucio Castilla

Date created

• 2017-04-27

Resource type

• Major Qualifying Project

Major

• Interdisciplinary

Rights statement

• In Copyright