Faculty Advisor

Adams, David S.

Center

University of Massachusetts Medical Center

Abstract

RUNX transcription factors are a family of DNA-binding proteins that function in development and hematopoiesis. Mixed Lineage Leukemias (MLL) are dependent on RUNX1 for oncogenic activity, but it is unclear whether MLLs are also affected by RUNX2. In this project, RUNX2 was knocked down in a variety of MLL-derived cell lines using shRNAs, and the levels of leukemic cell apoptosis were monitored by FACS. If found to be required for MLL, this would identify RUNX2 as a new therapeutic target.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2017

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Project Center

University of Massachusetts Medical Center

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