UMass medical school
Scientists have identified a total of 24 argonautes in C. elegans. However, there is still uncertainty as to the specific function of some of these worm-specific argonautes and the question remains as to which secondary argonautes are involved in the ALG-3/4 pathway and can the method for how they regulate their targets be uncovered. From male and sperm gene expression datasets, we have identified candidate secondary Argonautes that could be involved in the downstream function of the ALG-3/4 pathway (Unpublished data, Mello Lab). Here we report that the addition of the genetic mutants wago-1, wago-9, and wago-10 produce significantly lower broods and their compounded effect can be seen in the overall phenotype of the worm.
Worcester Polytechnic Institute
Biology and Biotechnology
Major Qualifying Project
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Chemistry and Biochemistry
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