Several models for prostate oncogenesis have been presented throughout the years, including the cancer stem cell (CSC) model. CSCs may be responsible for the self-renewing properties, and therefore progression, of the tumor. In this project, several protein and integrin markers were characterized using immunohistochemistry, immunofluorescence, and immunoblotting to identify cancer stem cells in human biopsy tissue. The data suggest that Alpha2 and Trop2 cannot be used to identify CSCs, and that using several markers simultaneously, including perhaps CD133, will be required to identify, and eventually isolate, cancer stem cells.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Rathore, Swati S

Contributors

• Goel, Hira Lal
• Languino, Lucia R.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-011510-131242

Advisor

• Adams, David S.

Year

• 2010

Sponsor

• UMass Medical School

Date created

• 2010-01-15

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

Last modified

• 2023-10-06