Faculty Advisor

Adams, David S.

Abstract

Several models for prostate oncogenesis have been presented throughout the years, including the cancer stem cell (CSC) model. CSCs may be responsible for the self-renewing properties, and therefore progression, of the tumor. In this project, several protein and integrin markers were characterized using immunohistochemistry, immunofluorescence, and immunoblotting to identify cancer stem cells in human biopsy tissue. The data suggest that Alpha2 and Trop2 cannot be used to identify CSCs, and that using several markers simultaneously, including perhaps CD133, will be required to identify, and eventually isolate, cancer stem cells.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2010

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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