Duffy, Joseph B.
Several types of cancer have been linked to the Epidermal Growth Factor Receptor (EGFR) family of tyrosine kinases. An EGFR homolog in Drosophila, dEGFR, was found to be inhibited by a protein called Kekkon1 (Kek1). Kek1 is a member of the LIG super family, meaning it contains both Leucine-rich repeats (LRRs) and Immunoglobulin (Ig) domains. Based on structural similarities it was hypothesized that members of the human LIG family could interact with the human members of the EGFR family. An ELEXIS interaction assay was used to test interactions between human LIGs and the EGFRs (ErbB1,2,4). Interactions between different human LIGs were also tested. Binding between the human LIGs and receptors could indicate the potential use of LIGs as a cancer therapeutic.
Worcester Polytechnic Institute
Major Qualifying Project
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Biology and Biotechnology
Chemistry and Biochemistry