Faculty Advisor

Duffy, Joseph B.

Faculty Advisor

Heilman, Destin

Abstract

Several types of cancer have been linked to the Epidermal Growth Factor Receptor (EGFR) family of tyrosine kinases. An EGFR homolog in Drosophila, dEGFR, was found to be inhibited by a protein called Kekkon1 (Kek1). Kek1 is a member of the LIG super family, meaning it contains both Leucine-rich repeats (LRRs) and Immunoglobulin (Ig) domains. Based on structural similarities it was hypothesized that members of the human LIG family could interact with the human members of the EGFR family. An ELEXIS interaction assay was used to test interactions between human LIGs and the EGFRs (ErbB1,2,4). Interactions between different human LIGs were also tested. Binding between the human LIGs and receptors could indicate the potential use of LIGs as a cancer therapeutic.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2018

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Department

Chemistry and Biochemistry

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