Faculty Advisor

Albrecht, Dirk

Faculty Advisor

Jain, Anjana

Abstract

Stem cell-based therapy shows promise as a strategy to treat a number of neurodegenerative diseases and injuries, such as Alzheimer’s Disease and Spinal Cord Injury. Currently, only 5-10% of neural stem cells (NSCs) survive the transplantation due to the procedure and the hostile environment once implanted. Therefore, a high-throughput method for encapsulating the NSCs, as well as producing uniform microgel spheres is necessary. A microfluidic system was designed to encapsulate live cells in microgel spheres. Specifically, a flow-focusing microfluidic device was used for its ability to produce a more consistent microgel sphere size as compared to other devices. A protocol for cell encapsulation was developed in order to successfully encapsulate live cells in microgel spheres.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2015

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

Share

COinS