Steroidal saponins have long been used indirectly in traditional Chinese herbal remedies, such as "Maidong". A tuber used in this medicine, Liriope muscari, yields the saponin (25R)-ruscogenin-1-yl β-D-xylopyranosyl-(1→3)-[β-D-glucopyranosyl- (1→2)]-β-D-fucopyranoside from which the sapogenin (25R)-ruscogenin is derived. This compound displays strong, unique, and useful anti- inflammatory and immunological properties and as such is a good candidate for analog exploration. Synthesis of some analogs of this steroid are detailed here.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Leitz, Keegan James

Contributors

• Domain, Emily

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042513-142357

Advisor

• Dittami, James P.

Year

• 2013

Sponsor

• Abbott Laboratories

Date created

• 2013-04-25

Resource type

• Major Qualifying Project

Major

• Chemistry

Rights statement

• In Copyright