Faculty Advisor

Dittami, James P.

Abstract

Steroidal saponins have long been used indirectly in traditional Chinese herbal remedies, such as "Maidong". A tuber used in this medicine, Liriope muscari, yields the saponin (25R)-ruscogenin-1-yl β-D-xylopyranosyl-(1→3)-[β-D-glucopyranosyl- (1→2)]-β-D-fucopyranoside from which the sapogenin (25R)-ruscogenin is derived. This compound displays strong, unique, and useful anti- inflammatory and immunological properties and as such is a good candidate for analog exploration. Synthesis of some analogs of this steroid are detailed here.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Chemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Your accessibility may vary due to other restrictions.

Share

COinS