Dittami, James P.
Steroidal saponins have long been used indirectly in traditional Chinese herbal remedies, such as "Maidong". A tuber used in this medicine, Liriope muscari, yields the saponin (25R)-ruscogenin-1-yl β-D-xylopyranosyl-(1→3)-[β-D-glucopyranosyl- (1→2)]-β-D-fucopyranoside from which the sapogenin (25R)-ruscogenin is derived. This compound displays strong, unique, and useful anti- inflammatory and immunological properties and as such is a good candidate for analog exploration. Synthesis of some analogs of this steroid are detailed here.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry