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Effects of Chonic and Acute Bisphenol-A Exposure on the Cellular Stress Response

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Stress granules (SGs) are cytoplasmic aggregates of mRNA and protein that form in response to environmental stress and are thought to confer protection from apoptosis. Bisphenol-A (BPA) is a ubiquitous environmental toxin linked to numerous diseases, though its relationship to SGs was previously unknown. BPA exposures within human serum levels had no significant effect on cell growth nor induced SG formation. However, high-dose acute BPA exposure greatly induced SG formation. Further, low-dose chronic BPA exposure resulted in a significant decrease in SG formation during subsequent high-dose acute BPA exposure, suggesting that chronic exposure to BPA alters cellular stress dynamics. Our results suggest that BPA may seriously alter the ability of cells to cope with environmental stress.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042915-160459
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  • 2015
Date created
  • 2015-04-29
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