Faculty Advisor

Buckholt, Michael Allan

Faculty Advisor

Farny, Natalie

Abstract

Stress granules (SGs) are cytoplasmic aggregates of mRNA and protein that form in response to environmental stress and are thought to confer protection from apoptosis. Bisphenol-A (BPA) is a ubiquitous environmental toxin linked to numerous diseases, though its relationship to SGs was previously unknown. BPA exposures within human serum levels had no significant effect on cell growth nor induced SG formation. However, high-dose acute BPA exposure greatly induced SG formation. Further, low-dose chronic BPA exposure resulted in a significant decrease in SG formation during subsequent high-dose acute BPA exposure, suggesting that chronic exposure to BPA alters cellular stress dynamics. Our results suggest that BPA may seriously alter the ability of cells to cope with environmental stress.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2015

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Department

BIO

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