Brodeur, Drew R
Kmiotek, Stephen J.
Sunovion Pharmaceuticals, Inc.
Sunovion Pharmaceuticals utilizes an organometallic rhodium-based catalyst in one of their drug production processes. Due to its high cost, it is beneficial to recover for reuse; however, due to the low concentration of the catalyst in the waste stream of the process, it has proven difficult to separate from solution. Our team investigated the use of polyelectrolytes and functionalized silica metal scavengers as a means to recover the catalyst. Through the use of the ICP-OES, rhodium concentrations were analyzed before and after the addition of the polyelectrolytes and metal scavengers. While the polyelectrolytes proved ineffective due to the lack of precipitation and inability to filter, the functionalized silica metal scavengers showed over 90% recovery of rhodium at various loadings.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry