Faculty Advisor

Adams, David S.

Faculty Advisor

Heilman, Destin

Abstract

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes. Despite improved therapy, relapsing pediatric patients have less than a 30% survival rate. It is therefore important to identify new drug targets for treatment of relapsed T-ALL. In this project,TOX, which is over-expressed in human T-ALL was studied for modulating T-ALL pathogenesis. Through a zebrafish transgenic screen, Tox was shown to act as a collaborating oncogene that increased T-ALL aggression. Data suggest that Tox over-expression results in a HOX11 signature characteristic of rapid cell division, and likely induces molecular pathways in T-ALL pathogenesis unlike T-ALLs expressing only Myc. Uncovering the TOX-regulated molecular pathways may help identify novel drug targets for T-ALL treatment.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2013

Major

Interdisciplinary

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Department

Chemistry and Biochemistry

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