Faculty Advisor

Heilman, Destin

Faculty Advisor

Prusty Rao, Reeta

Abstract

An infertile C. elegans mutant fer-1 was identified as a suitable substitute for wild type in evaluating the pathogenesis of C. albicans using a survival assay. The response of fer-1 mutant worms infected with avirulent C. albicans mutants or treated with fluconazole is statistically indistinguishable from the wildtype counterpart. The lifespan of uninfected fer-1 worms is marginally yet reproducibly shorter than wildtype, but the lack of progeny in sterile mutants makes them an ideal choice for otherwise labor-intensive lifespan analyses.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2012

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Advisor Department

Biology and Biotechnology

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