Faculty Advisor

Rulfs, Jill

Abstract

The aim of this study was to determine whether the apparent reduction in cell number and alpha-SMA expression of porcine mitral valvular interstitial cells plated on substrates of varying stiffness was due to apoptosis or dedifferentiation. This decrease was determined to be a result of apoptosis as indicated by caspase levels comparable to the positive control. A more thorough investigation into cellular communication and signaling will be invaluable to the development of next generation valve replacements.

Publisher

Worcester Polytechnic Institute

Date Accepted

December 2006

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Share

COinS