Faculty Advisor

Ryder, Elizabeth F.

Abstract

The C. elegans protein MIG-10 is a cytoplasmic signaling protein known to facilitate neuronal migrations during development of the worm. LIN-53 is a nucleosome remodeling factor associated with transcriptional repression in C. elegans. Biochemical analyses were performed using co-immunoprecipitation and western blotting techniques to assess the interaction of these two proteins. Preliminary results suggest a potential interaction between LIN-53 and MIG-10. Work is in progress to determine whether lin-53 mutations affect neuronal migrations in C. elegans.

Publisher

Worcester Polytechnic Institute

Date Accepted

June 2012

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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