The C. elegans protein MIG-10 is known to facilitate the connections between surface guidance signals with cellular responses during neuronal migration. Mutations in mig-10 result in defects in axon guidance, neuronal migration, and excretory canal outgrowth. Strains were constructed using GFP markers and mig-10 genomic constructs and were used to determine which MIG-10 isoforms are necessary to rescue mig-10 defects. Quantitative results indicate that either MIG-10A or B or both isoforms are sufficient to rescue defects in both excretory canal and cell migration. Cell-autonomous expression of MIG-10A can rescue migration of ALM neurons.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Zhang, Subaiou

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042910-141211

Advisor

• Ryder, Elizabeth F.

Year

• 2010

Date created

• 2010-04-29

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

Last modified

• 2021-02-02