Faculty Advisor

Ryder, Elizabeth F

Abstract

The C. elegans protein MIG-10 is known to facilitate the connections between surface guidance signals with cellular responses during neuronal migration. Mutations in mig-10 result in defects in axon guidance, neuronal migration, and excretory canal outgrowth. Strains were constructed using GFP markers and mig-10 genomic constructs and were used to determine which MIG-10 isoforms are necessary to rescue mig-10 defects. Quantitative results indicate that either MIG-10A or B or both isoforms are sufficient to rescue defects in both excretory canal and cell migration. Cell-autonomous expression of MIG-10A can rescue migration of ALM neurons.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2010

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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