Faculty Advisor

Dittami, James P.

Abstract

The concerted [3+2] ylide-alkene photocyclization proceeds through trans-fused ylide intermediates. This reaction has been demonstrated to produce multicyclic heterocycles with up to six chiral centers in excellent yields from simple starting materials. This reaction can be used to develop novel compounds toward the discovery of new pharmacophores. Developments toward an asymmetric variant of this reaction have been undertaken.

Publisher

Worcester Polytechnic Institute

Date Accepted

May 2010

Major

Chemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Share

COinS