Rolle, Marsha Whitney
University of Massachusetts Medical Center
Umass Medical: Paul Kaufman
The cost of treating a Candida albicans infection for urinary catheters exceeds $200 million per year due to increasing resistance to antifungal drugs. Using a small molecule called Filastatin that affects cell morphology, we developed several approaches to integrate the molecule into silicone catheters to prevent cell adhesion. Utilizing a cell adhesion assay, we screened the various designs to classify which had the greatest impact on preventing cell adhesion. We found through testing that absorption of the molecule had the most influence compared to the other alternatives. In addition, we determined through a cost analysis that this method could be cheaper compared to what is currently on the market for antifungal catheters.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry
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