Faculty Advisor

Heilman, Destin

Faculty Advisor

Rolle, Marsha Whitney

Center

University of Massachusetts Medical Center

Abstract

The cost of treating a Candida albicans infection for urinary catheters exceeds $200 million per year due to increasing resistance to antifungal drugs. Using a small molecule called Filastatin that affects cell morphology, we developed several approaches to integrate the molecule into silicone catheters to prevent cell adhesion. Utilizing a cell adhesion assay, we screened the various designs to classify which had the greatest impact on preventing cell adhesion. We found through testing that absorption of the molecule had the most influence compared to the other alternatives. In addition, we determined through a cost analysis that this method could be cheaper compared to what is currently on the market for antifungal catheters.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2016

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Advisor Department

Biomedical Engineering

Project Center

University of Massachusetts Medical Center

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