Faculty Advisor

Camesano, Terri Anne

Faculty Advisor

McGimpsey, W. Grant

Center

Nancy, France

Abstract

A collaboration between WPI and ENSIC was undertaken to investigate the properties of emulsions as a drug delivery system. Biocompatible amphiphilic polymers are used as emulsifiers for controlled drug delivery. They act as a barrier between phases in oil-in-water emulsions to increase stability. Oil soluble drugs can be encapsulated within the oil nanoparticles and released into a biological system. The goal of this project was to study modified dextran (DexC6), an amphiphilic polymer. The most stable emulsions were formed with a DexC6 aqueous concentration of 40g/L in a system of 40% octyldodecanol oil volume. Drug release kinetic experiments showed that encapsulated lidocaine is released at a slower rate than free lidocaine. Further research in emulsion drug delivery is recommended.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2006

Major

Chemical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemical Engineering

Advisor Department

Chemistry and Biochemistry

Project Center

Nancy, France

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