Faculty Advisor

Adams, David S.

Abstract

The Dopamine Transporter (DAT) is a trans-membrane protein that binds dopamine and transports it into the cell, removing it from the synapse and terminating the signal to the post-synaptic cell. The endocytic pathway by which DAT internalizes is yet unknown. Dynamin is a GTPase that is known to be involved in the budding of vesicles during some endocytic pathways. The present study was performed to determine if DAT internalizes via a dynamin-dependent endocytic pathway. Data shows that DAT internalization is not dynamin-dependent and implicates that dynamin may be involved in recycling DAT to the cell surface.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2012

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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