Faculty Advisor

Duffy, Joseph B

Abstract

The Epidermal Growth Factor Receptor (EGFR/ErbB) receptor tyrosine kinase (RTK) family has been implicated in numerous cancer types (e.g. lung, breast and brain) and this signaling network is conserved from Drosophila to humans. For this reason, Drosophila may provide an ideal in vivo system for experimental analyses of this pathway and a chemical genetics approach to the identification of therapeutics against it. Towards this goal, an assay utilizing Drosophila transgenic for members of the human ErbB family was developed for screening putative inhibitory compounds. Preliminary phenotypic data with known EGFR inhibitors yielded promising results.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2007

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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