The Epidermal Growth Factor Receptor (ErbB1-4) family of tyrosine kinases has been associated with many cancer types. Members of the human LIG family, transmembrane proteins containing leucine-rich repeats and immunoglobulin domains, have been proposed to interact with ErbB1-4. Using the documented Drosophila LIG, Kekkon 1, and EGFR interaction, an extracellular interaction assay, ELEXIS, was developed to screen for novel human LIG/ErbB1-4 interactions. Any human LIGs interacting with ErbB1-4 could have the potential to be used as a cancer therapeutic.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Mazza, Julie Marie

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-050116-194118

Advisor

• Duffy, Joseph B.

Year

• 2016

Date created

• 2016-05-01

Location

• Worcester

Resource type

• Major Qualifying Project

Major

• Interdisciplinary

Rights statement

• In Copyright