Faculty Advisor

Duffy, Joseph B.

Abstract

The Epidermal Growth Factor Receptor (ErbB1-4) family of tyrosine kinases has been associated with many cancer types. Members of the human LIG family, transmembrane proteins containing leucine-rich repeats and immunoglobulin domains, have been proposed to interact with ErbB1-4. Using the documented Drosophila LIG, Kekkon 1, and EGFR interaction, an extracellular interaction assay, ELEXIS, was developed to screen for novel human LIG/ErbB1-4 interactions. Any human LIGs interacting with ErbB1-4 could have the potential to be used as a cancer therapeutic.

Publisher

Worcester Polytechnic Institute

Date Accepted

May 2016

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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