The family of ser/thr proteins known as Aurora kinases (Aur) have been shown to play an important role in cell cycle progression in mitotic cells. During meiosis, AurA is required for proper microtubule organization and establishing spindle integrity. This study investigated the effects of demecolcine, a microtubule destabilizing drug, on spindle localization of AurA in activated CF-1 mouse oocytes. Marked differences were observed between controls and demecolcine treated oocytes with respect to the disregulated spatial distribution of AurA.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Tatem, Jessica L.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042706-130953

Advisor

• Overstrom, Eric W.

Year

• 2006

Date created

• 2006-04-27

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright