The Gaudette Laboratory’s fibrin sutures deliver stem cells to infarcted myocardium with high engraftment rates, yet seeded cells remain immature and incapable of generating sufficient contractile force. The device cyclically loads seeded sutures in an incubator at 10-15% strain and frequency of 1-3 Hz, which research suggests, promotes stem cell development into mature cardiomyocytes. The design additionally makes live imaging possible without termination of the experiment. This device allows researchers to further study the effect of cyclic strain on cardiomyocyte maturation.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Rielly, Kate Marie
• Flannery, Thomas M
• Molica, Mr. Gregory
• Rumpf, Nathan Frederick

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042617-101939

Advisor

• Ji, Songbai
• Gaudette, Glenn R.

Year

• 2017

Date created

• 2017-04-26

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright