Faculty Advisor

Buckholt, Michael Allan

Faculty Advisor

Shell, Scarlet


Antibiotic resistance has increased for many different diseases including tuberculosis. Scientists have begun to seek ways and places to discover new antibiotics to combat this resistance. Studies over the last 60 years suggest that pathogen-inhibiting bacteria can be found in soil. A number of bacterial isolates potentially producing antibiotic compounds have been found in the soil by students in the Microbes to Molecules laboratory course at Worcester Polytechnic Institute (WPI). This project tested those isolates for the ability to inhibit the growth of Mycobacterium smegmatis, a model bacteria for Mycobacterium tuberculosis. The goal of the project described here was to identify isolates capable of inhibiting M. smegmatis and determine the mechanism(s) of inhibition.


Worcester Polytechnic Institute

Date Accepted

April 2017


Biology and Biotechnology

Project Type

Major Qualifying Project



Advisor Department

Biology and Biotechnology