Camesano, Terri Anne
Antibiotic-resistant bacteria and chronic wound infections pose a serious threat to patient health and overall quality of life. The goal of this project was to determine the action mechanism of fCBD-LL37 against phosphatidylcholine lipid bilayer using a quartz crystal microbalance with dissipation. At increased concentrations, fCBD interacted to a greater extent with the lipid bilayer indicating that the tethered fCBD-LL37 shows greater peptide bondage to bilayer. This is the foundation of the development of bipolymer-tethered AMPs for wound healing applications.
Worcester Polytechnic Institute
Major Qualifying Project
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