Antibody Drug Conjugates (ADCs) represent a rapidly growing and extensively potent class of pharmaceuticals that utilize antibodies to deliver toxic chemicals directly to tumors and other dangerous cells while avoiding healthy tissues. This technology is based on the controlled yet spontaneous release of a drug compound via the domino-like cascade effect of the self-immolative spacer system p-aminobenzyl alcohol (PABOH). This report seeks to investigate the effects that various PABOH analogues have on the kinetics of spacer degradation, in an effort to optimize the efficiency of the ADC in a therapeutic context.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Domain, Emily Hilda

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-012914-153355

Advisor

• Dittami, James P.

Year

• 2014

Sponsor

• Abbott Bioresearch Center

Date created

• 2014-01-29

Resource type

• Major Qualifying Project

Major

• Chemistry

Rights statement

• In Copyright